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Target intelligence / Profile preview
Sodium-sulfate cotransporter 1 (NaS1)
- Target
- NaS1
- Molecular classification
- Transporter, Solute carrier family (SLC13A1), Ion transporter
01
Overview
Sodium-sulfate cotransporter 1 (NaS1, also known as NaSi-1 or SLC13A1) is a membrane-bound transporter predominantly expressed on the apical membrane of renal proximal tubule cells, where it mediates the sodium-dependent uptake of sulfate ions from the filtrate into renal epithelial cells, playing a fundamental role in the maintenance of systemic sulfate balance. Disruption of NaS1 activity leads to altered renal sulfate reabsorption and can disturb sulfate homeostasis in mammals. Although NaS1/SLC13A1 is not a prominent therapeutic target in current pharmacology, it is essential for normal renal and metabolic function[4].
- Other names
- NaSi-1NaS1sodium sulfate cotransporterSlc13a1
02
Mechanism of action
Not typically a drug target; theoretical mechanism would be competitive or non-competitive inhibition of sulfate transport.
03
Biological functions
Sulfate reabsorption in renal proximal tubuleRegulation of sulfate homeostasis
04
Disease associations
Disturbances in sulfate homeostasis (inferred)Potential involvement in disorders of renal ion transport and homeostasis (inferred)
05
Safety considerations
Disturbance may affect systemic sulfate levels and related metabolic processes.
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