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Target intelligence / Profile preview
Sodium Taurocholate Co-Transporter Polypeptide (NTCP)
- Target
- NTCP
- Molecular classification
- Transporter, Membrane Transport Protein, Solute Carrier
01
Overview
Sodium taurocholate co-transporter polypeptide (NTCP) is a sodium-dependent transmembrane transporter protein primarily expressed in the basolateral membrane of hepatocytes in the liver. It plays a central role in the hepatic uptake of conjugated bile acids from plasma, which is essential for maintaining enterohepatic circulation and overall bile acid homeostasis. NTCP is also an essential cell surface receptor for hepatitis B virus (HBV) and hepatitis D virus (HDV), enabling viral entry into human hepatocytes. Inhibitors targeting NTCP are being explored to prevent HBV/HDV infection by blocking viral access to hepatocytes.
- Other names
- SLC10A1Sodium taurocholate cotransporting polypeptide
02
Mechanism of action
Inhibition of NTCP to block viral entry or modulate bile acid metabolism
03
Biological functions
Bile acid transportEnterohepatic circulationHepatic uptakeViral entry receptor (HBV/HDV)
04
Disease associations
HypercholanemiaHepatitis BHepatitis DCholestasis
05
Safety considerations
Potential disruption of bile acid homeostasisCompensatory mechanisms by other transportersOff-target effects on steroid/thyroid hormone transport
06
Biomarkers
Plasma bile salt levelsNTCP expression levels
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