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Target intelligence / Profile preview
Sodium Taurocholate Co-Transporting Polypeptide (NTCP)
- Target
- NTCP
- Molecular classification
- Transporter, Solute carrier family
01
Overview
Sodium taurocholate co-transporting polypeptide (NTCP) is a sodium-dependent transporter protein primarily expressed on the basolateral membrane of hepatocytes in the liver. It plays a central role in hepatic bile acid uptake and homeostasis, as well as serving as an essential entry receptor for hepatitis B virus (HBV) and hepatitis D virus.
- Other names
- SLC10A1Sodium taurocholate cotransporting polypeptide
02
Mechanism of action
Inhibition of bile acid transport; competitive inhibition of viral binding
03
Biological functions
Bile acid transportHepatocyte uptakeEnterohepatic circulation regulationViral entry receptor
04
Disease associations
Hepatitis BHepatitis DCholestasisLiver diseaseDiet-induced obesity (animal models)
05
Safety considerations
Potential drug-drug interactions due to altered hepatic uptakeCompensatory mechanisms by other transporters in NTCP deficiency
06
Interacting drugs
Bulevirtide (Myrcludex B)
7 more in the full profile.
07
Biomarkers
Plasma bile salt levelsNTCP expression levels in hepatocytes
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