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Target intelligence / Profile preview
Na+-taurocholate cotransporting polypeptide (NTCP)
- Target
- NTCP
- Molecular classification
- Transporter, Solute carrier family 10 member 1
01
Overview
Na+-taurocholate cotransporting polypeptide (NTCP), also known as SLC10A1, is a sodium-dependent transporter protein predominantly expressed in the basolateral membrane of hepatocytes. It plays a central role in hepatic uptake of bile acids, steroid hormones, and thyroid hormones, and also functions as a receptor for hepatitis B and D viruses.
- Other names
- SLC10A1Sodium taurocholate cotransporting polypeptide
02
Mechanism of action
Inhibition of NTCP-mediated transport and/or viral entry
03
Biological functions
Bile acid transportSteroid hormone transportThyroid hormone transportHBV/HDV receptor
04
Disease associations
Inherited hypercholanemiaHepatitis BHepatitis DDiet-induced obesityCholestatic liver injury
05
Safety considerations
Elevated serum/plasma levels of bile saltsCompensatory mechanisms by other transporters
06
Interacting drugs
Myrcludex B
8 more in the full profile.
07
Biomarkers
Plasma bile salt levelsNTCP expression levels
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