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Target intelligence / Profile preview
Sodium voltage-gated channel alpha subunit 9 (NaV1.7)
- Target
- NaV1.7
- Molecular classification
- Ion channel, Voltage-gated sodium channel
01
Overview
The sodium voltage-gated channel alpha subunit 9 (NaV1.7) is a critical component of voltage-gated sodium channels, essential for generating and conducting action potentials in excitable cells, particularly neurons. Predominantly expressed in nociceptors, it amplifies small depolarizations, enabling the neuron to reach the threshold for firing an action potential. Mutations in SCN9A can lead to altered pain perception, including congenital insensitivity to pain (loss-of-function) and pain syndromes like primary erythromelalgia (gain-of-function).
- Other names
- SCN9A
02
Mechanism of action
Sodium channel blockade
03
Biological functions
Action potential initiationAction potential propagationNociceptionPain signaling
04
Disease associations
Congenital insensitivity to painPrimary erythromelalgiaParoxysmal extreme pain disorderPain syndromes
05
Interacting drugs
Tetrodotoxin
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