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Target intelligence / Profile preview
Solid Tumor Antigen (STA)
- Target
- STA
- Molecular classification
- Protein, Glycoprotein
01
Overview
Solid tumor antigen refers collectively to molecular markers exploited as therapeutic targets across diverse types of non-blood cancers. Most current clinical strategies focus on TAAs rather than truly unique TSAs due to their broader applicability despite increased safety concerns stemming from shared expression with some healthy tissues.
- Other names
- Tumor-Associated AntigenTumor-Specific AntigenTAATSA
02
Mechanism of action
Targeted cell killing via immune response or cytotoxic drug delivery
03
Biological functions
Immune recognitionCell signalingCell proliferationCell survivalAngiogenesis
04
Disease associations
Cancer
05
Safety considerations
Off-target toxicityOn-target/off-tumor toxicityCytokine release syndrome (CRS)NeurotoxicityTumor heterogeneityAntigen sheddingLimited therapeutic window
06
Interacting drugs
CAR-T cells
3 more in the full profile.
07
Biomarkers
HER2 expression levelEGFR expression levelPSMA expression levelCEA expression levelMUC1 expression levelGD2 expression levelMesothelin expression levelTROP2 expression level
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