Solid tumor-associated surface antigen (TAA)

The term 'Solid tumor-associated surface antigen' is a broad, non-specific classification used to describe any protein, glycoprotein, or glycolipid expressed on the extracellular surface of solid tumor cells that can serve as a site for therapeutic binding (National Cancer Institute, 2023). This category encompasses a wide variety of molecules, including lineage-specific markers, overexpressed growth factor receptors, and neoantigens resulting from somatic mutations. In early-stage drug discovery, a therapeutic candidate may be identified that binds to a tumor cell surface before the specific molecular identity of the antigen is known; in such cases, the target is often referred to as 'unknown' (Nature Reviews Drug Discovery, 2021). Because this term refers to a heterogeneous group of molecules rather than a single, defined biological entity, it cannot be assigned specific molecular classifications, biological functions, or a singular mechanism of action. Consequently, it is considered an incorrect or overly broad entry for a structured target database.

Other names

Tumor-associated antigenTumor-specific antigenTSASurface tumor antigenUnidentified tumor antigen

Not applicable for a generic category of antigens.