Soluble and tissue-associated proteins

The term "Soluble and tissue-associated proteins" refers to a high-level classification used in pharmacological databases, such as ChEMBL, to categorize proteins that are not integral membrane-bound entities like receptors or ion channels (Gaulton et al., 2012). This category is highly heterogeneous, encompassing a wide variety of molecules including secreted enzymes, cytokines, growth factors, and structural proteins of the extracellular matrix. Because it represents a broad organizational label rather than a single molecular entity, it is not a valid therapeutic target for drug discovery. Instead, it serves to distinguish these proteins from other classes in large-scale bioactivity datasets (Mendez et al., 2019). Specific therapeutic targets that fall under this classification include well-known proteins like Tumor Necrosis Factor-alpha (TNF-alpha), various interleukins, and matrix metalloproteinases (MMPs), each of which has its own specific biological functions and disease associations. For analysts, data associated with this target type should be disaggregated into individual protein targets to assess therapeutic potential or competitive landscapes accurately. Consequently, there are no specific drugs, mechanisms of action, or biomarkers associated with this general classification as a whole.

Other names

ChEMBL Target Type: SOLUBLE AND TISSUE-ASSOCIATED PROTEINSSoluble proteinsTissue-associated proteins

Not applicable