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Soluble Epoxide Hydrolase (sEH)
- Target
- sEH
- Molecular classification
- Enzyme, Epoxide hydrolase, Lipid-phosphate phosphatase
01
Overview
Soluble epoxide hydrolase (sEH) is a bifunctional enzyme that regulates the levels of bioactive lipids such as epoxyeicosatrienoic acids (EETs). It is involved in various physiological processes, including vascular tone, inflammation, pain perception, and cholesterol metabolism. Inhibition of sEH is being explored as a therapeutic strategy for hypertension, inflammation-related diseases, neuropathic pain, cardiovascular protection, metabolic disorders, and neurodegenerative diseases.
- Other names
- EPHX2Epoxide hydrolase 2
02
Mechanism of action
Inhibition of sEH stabilizes beneficial lipid mediators like EETs, impacting vascular tone, inflammation, pain, and cholesterol metabolism.
03
Biological functions
Epoxide hydrolysisLipid-phosphate hydrolysisRegulation of vascular toneRegulation of inflammationRegulation of pain perceptionRegulation of cholesterol metabolism
04
Disease associations
Familial hypercholesterolemiaHypertension (potential role)Neurodegenerative disease (potential role)Pain (potential role)Cardiovascular disease (potential role)Inflammation-related diseases (potential role)Metabolic disorders (potential role)
05
Safety considerations
Poor water solubility and high melting points for some sEH inhibitor classes present drug development challenges.Potential for off-target effects of sEH inhibitors.
06
Interacting drugs
sEH inhibitors (e.g., urea derivatives)
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