Soluble fms-like tyrosine kinase 1 (sFlt-1)

Soluble fms-like tyrosine kinase-1 (sFlt-1), also known as soluble vascular endothelial growth factor receptor 1 (sVEGFR-1), is a truncated splice variant of the VEGF receptor Flt-1. It acts as a decoy receptor with antiangiogenic properties by binding and sequestering angiogenic factors such as vascular endothelial growth factor (VEGF) and placental growth factor (PlGF), thereby reducing their bioavailability and inhibiting blood vessel formation. Elevated levels are associated with preeclampsia and chronic kidney disease.

Other names

sVEGFR-1soluble vascular endothelial growth factor receptor 1sFLT‑i13sFLT‑e15a

Binds and sequesters VEGF and PlGF, preventing them from binding to their cell-surface receptors and inhibiting downstream signaling pathways involved in angiogenesis.