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Soluble Guanylyl Cyclase Beta-1 Subunit (sGCβ1 (Soluble Guanylyl Cyclase Beta-1) or GUCY1B1)
- Target
- sGCβ1 (Soluble Guanylyl Cyclase Beta-1) or GUCY1B1
- Molecular classification
- Enzyme
01
Overview
The Soluble Guanylyl Cyclase Beta-1 Subunit is part of the heterodimeric enzyme that catalyzes the conversion of GTP to cGMP, a key signaling molecule involved in vasodilation and other physiological processes. It works in conjunction with the alpha subunit and is activated by nitric oxide binding to its heme group, significantly increasing its enzymatic activity. This enzyme plays a crucial role in cardiovascular health by mediating vasodilation and inhibiting platelet aggregation.
- Other names
- GUCY1B1GCS-beta-1Guanylate Cyclase Soluble Subunit Beta-1
02
Mechanism of action
Activation of soluble guanylyl cyclase enhances the conversion of GTP to cGMP, leading to vasodilation and other signaling effects.
03
Biological functions
Signal transductioncGMP biosynthesisNitric oxide mediated signal transduction
04
Disease associations
Cardiovascular diseaseBartter Syndrome, Type 2Nemaline Myopathy 5A
05
Safety considerations
Reduced efficacy in conditions with low nitric oxide availability or oxidative stress
06
Interacting drugs
Riociguat
2 more in the full profile.
07
Biomarkers
cGMP levels
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