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Soluble NSF Attachment Protein Receptor
- Molecular classification
- Membrane Fusion Protein, Receptor
01
Overview
Soluble NSF attachment protein receptors (SNAREs) are a family of proteins essential for membrane fusion within cells. They mediate the docking and fusion of vesicles with target membranes during intracellular vesicular transport and exocytosis. SNAREs form a stable complex, the SNARE complex, facilitating membrane fusion. After fusion, the complex is disassembled by NSF, an ATPase, with assistance from SNAPs. Multiple isoforms exist with cell-type specific expression and regulation by phosphorylation.
- Other names
- SNAREv-SNAREt-SNARESNAP23SNAP25VAMP8Syntaxin
02
Mechanism of action
Facilitates membrane fusion by forming a stable SNARE complex, driving membrane apposition and subsequent fusion. Complex disassembly is ATP-dependent.
03
Biological functions
Vesicular TransportExocytosisMembrane FusionProtein-protein interaction
04
Disease associations
Neurological DisordersInfection
05
Safety considerations
Disruption can lead to impaired neurotransmitter release and neurological disorders.Pathogens can hijack SNARE machinery.
06
Interacting drugs
N-ethylmaleimide
1 more in the full profile.
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