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Target intelligence / Profile preview
Soluble Resistance-related Calcium-binding protein (SRI)
- Target
- SRI
- Molecular classification
- Penta-EF-hand calcium-binding protein
01
Overview
Sorcin is a calcium-binding protein involved in regulating intracellular calcium homeostasis. It interacts with multiple calcium channels and transporters, impacting processes such as excitation-contraction coupling and apoptosis. It is highly expressed in some cancers and contributes to multidrug resistance.
- Other names
- Sorcin
02
Mechanism of action
Direct inhibition or downregulation via RNA interference or small molecules aimed at restoring chemosensitivity or inducing apoptosis selectively within resistant tumor cells.
03
Biological functions
Calcium homeostasis regulationModulation of ryanodine receptor (RyR)Modulation of sarco/endoplasmic reticulum Ca²⁺ ATPase (SERCA)Modulation of Na⁺/Ca²⁺ exchanger (NCX)Modulation of L-type voltage-operated Ca²⁺ channels (VOCC)Regulation of apoptosis
04
Disease associations
CancerMultidrug resistanceDiabetes mellitus complicationsNeurodegenerative diseases
05
Safety considerations
Potential for affecting calcium homeostasis in healthy tissues
06
Biomarkers
Sorcin overexpression in cancer tissues
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