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Target intelligence / Profile preview
Soluble Urokinase Plasminogen Activator Receptor (suPAR)
- Target
- suPAR
- Molecular classification
- Receptor, Glycoprotein
01
Overview
Soluble urokinase plasminogen activator receptor (suPAR) is the circulating, soluble form of the membrane-bound urokinase plasminogen activator receptor (uPAR), also known as CD87. It is primarily expressed on immune cells, endothelial cells, and smooth muscle cells. suPAR results from proteolytic cleavage of uPAR during inflammation or immune activation. Elevated levels of suPAR are associated with increased activation of the immune system and correlate with disease severity across various acute/chronic diseases, predicting morbidity/mortality risk. It plays roles in receptor activity, cell adhesion & migration, chemotaxis, and angiogenesis.
- Other names
- uPARCD87Soluble uPAR
02
Mechanism of action
Modulation of uPA activity, integrin signaling, and cell adhesion/migration.
03
Biological functions
Receptor ActivityCell AdhesionCell MigrationChemotaxisAngiogenesisFibrinolysisTissue RemodelingImmune Response
04
Disease associations
SepsisChronic Kidney DiseaseCardiovascular DiseasesCancerInflammationGlomerular filtration barrier dysfunction
05
Biomarkers
Disease severityDisease aggressivenessMorbidity riskMortality riskCKD progressioneGFRProteinuria
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