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Target intelligence / Profile preview
Solute carrier family 10 member 7 (SLC10A7)
- Target
- SLC10A7
- Molecular classification
- Transporter, Solute carrier family, Membrane protein, Seven-transmembrane protein
01
Overview
Solute carrier family 10 member 7 (SLC10A7) encodes a membrane protein localized primarily in the endoplasmic reticulum, Golgi apparatus, and plasma membrane. Despite its classification within the sodium/bile acid cotransporter family, SLC10A7 does not transport bile acids or steroid conjugates—unlike other SLC10 family members. Instead, it plays a critical role in extracellular matrix production by facilitating glycosaminoglycan and glycoprotein synthesis and trafficking, essential for bone and teeth development and proper mineralization. SLC10A7 also contributes to the regulation of intracellular calcium homeostasis. Loss-of-function mutations are associated with skeletal anomalies and glycosylation disorders, but its physiological substrates remain unknown and it lacks established pharmacological modulators.
- Other names
- Sodium/bile acid cotransporter 7C4orf13P7SSASKSNTCP7MGC25043DKFZp566M114DKFZp313H0531DKFZp779O2438SBF-domain containing protein
02
Biological functions
Bone developmentTeeth developmentBiosynthesis and trafficking of glycosaminoglycans and glycoproteinsExtracellular matrix mineralizationRegulation of cellular calcium homeostasis
03
Disease associations
Short statureAmelogenesis imperfectaSkeletal dysplasia with scoliosisCongenital disorders of glycosylation
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