Solute carrier family 11 member 1 (SLC11A1)

SLC11A1, also known as Natural resistance-associated macrophage protein 1 (NRAMP1), is a multipass membrane protein located primarily in late endosomal and lysosomal membranes of macrophages, dendritic cells, and some leukocyte populations[1][2]. Functioning mainly as a proton-coupled divalent metal ion transporter, it plays a key role in regulating iron and manganese homeostasis within immune cells. SLC11A1 is critical for mounting effective immune responses to a range of intracellular pathogens (including Mycobacterium, Leishmania, Salmonella), influencing both antigen processing/presentation and cytokine production. Genetic variation in SLC11A1 is linked to human susceptibility to infectious diseases, as well as risk for immune-mediated conditions such as type 1 diabetes and some cancers. Dysfunction or altered regulation can shift immune responses, affecting Th1/Th2 balance and inflammasome signaling, and may promote pathology ranging from chronic infection to autoimmunity and malignancy[1][2].

Other names

Natural resistance-associated macrophage protein 1NRAMP1NRAMP 1LSHItyBcg

Drugs or agents affecting SLC11A1 modulate macrophage activation, metal ion transport, and inflammatory pathways, mainly through altering cytokine production, antigen presentation, and generation of toxic radicals[2].