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Solute Carrier Family 12 Member 1 (NKCC2)
- Target
- NKCC2
- Molecular classification
- Transporter, Solute Carrier, Ion Transporter, Cotransporter
01
Overview
Solute carrier family 12 member 1 (SLC12A1), also known as NKCC2, is a membrane protein that functions as a sodium-potassium-chloride cotransporter. It is primarily expressed in the kidney, specifically on the luminal membrane of epithelial cells in the thick ascending limb of the loop of Henle. This transporter plays a critical role in renal salt reabsorption and overall fluid and electrolyte balance. Mutations in SLC12A1 are associated with Bartter syndrome type I.
- Other names
- Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1 (BSC1)Kidney-specific Na-K-Cl symporterNa-K-2Cl cotransporter 2Sodium/potassium/chloride cotransporter 2
02
Mechanism of action
Inhibition of Na+/K+/2Cl- cotransport
03
Biological functions
Sodium transportPotassium transportChloride transportSalt reabsorptionRegulation of body fluid levelsMaintenance of blood pressureIonic homeostasis
04
Disease associations
Bartter syndrome type IHypertension
05
Safety considerations
Electrolyte imbalances (hypokalemia, metabolic alkalosis) due to excessive salt wasting.
06
Interacting drugs
Furosemide
4 more in the full profile.
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