Solute carrier family 12 member 3 pseudogene

The "solute carrier family 12 member 3 pseudogene" is a segment of DNA with high sequence similarity to the functional SLC12A3 gene, which encodes the thiazide-sensitive sodium-chloride co-transporter. Unlike the active gene, the pseudogene version does not produce a functional protein and does not serve as a transporter or therapeutic target. Pseudogenes can arise by gene duplication or retrotransposition events and are often non-functional, though in rare cases they may regulate related genes. This pseudogene has no known physiological or pathological significance in humans, in contrast to the active SLC12A3 gene, which plays a key role in kidney electrolyte handling and is the target of thiazide diuretics for hypertension[2]. Key clarification: The functional gene “solute carrier family 12 member 3” (SLC12A3) is clinically relevant and encodes the sodium-chloride co-transporter targeted by thiazide diuretics, but the “pseudogene” version, as specified in your query, is not a protein, not a therapeutic target, and is often included in gene databases only for genomic annotation purposes[2]. If your interest is in the therapeutically relevant transporter, data for "SLC12A3" (not the pseudogene) should be referenced instead[1][3][4].

Other names

SLC12A3PSLC12A3 pseudogenesolute carrier family 12 member 3 pseudogene