Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Solute carrier family 12 member 5 (KCC2)
- Target
- KCC2
- Molecular classification
- Transporter, Solute Carrier Family
01
Overview
Solute carrier family 12 member 5 (SLC12A5), also known as KCC2, is a neuron-specific potassium-chloride cotransporter responsible for establishing the chloride ion gradient in neurons. It maintains low intracellular chloride concentrations, critical for synaptic inhibition via GABAergic signaling and cellular protection against excitotoxicity. KCC2 also plays a role in neuroplasticity and is implicated in epilepsy, Rett syndrome, colorectal cancer, and hepatocellular carcinoma. In cancer it can promote tumor growth/metastasis via gene amplification/overexpression.
- Other names
- Potassium-chloride transporter member 5Chloride potassium symporter 5EIEE34EIG14hKCC2DEE34
02
Mechanism of action
Not applicable; target of therapeutics but no approved drugs directly target it.
03
Biological functions
Neuronal Cl^-/K^+ cotransportMaintenance of low neuronal Cl^- concentrationSynaptic inhibitionNeuroplasticityRegulation of dendritic spine formationCell proliferationApoptosis
04
Disease associations
Epilepsy syndromesRett syndromeColorectal cancerHepatocellular carcinoma
05
Safety considerations
Potential for severe motor deficitsEpileptiform activitySpasticityRespiratory failure
Beyond the preview
Go deeper on Solute carrier family 12 member 5 (KCC2).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Solute carrier family 12 member 5 (KCC2).