Solute carrier family 13 member 2 (SLC13A2)

Solute carrier family 13 member 2, encoded by the SLC13A2 gene, is a low-affinity sodium-dicarboxylate cotransporter found primarily in the renal proximal tubule and the small intestine. It facilitates secondary active transport of divalent dicarboxylate ions—including citrate, succinate, fumarate, and alpha-ketoglutarate—using the sodium gradient across the plasma membrane. Its function is critical for the reabsorption and homeostasis of citric acid cycle intermediates in the body. SLC13A2 activity influences urinary citrate excretion and plays a central role in protection against kidney stone formation. Mutations or altered activities of SLC13A2 are associated with nephrolithiasis and rare developmental/epilepsy syndromes. The protein works as an electrogenic symporter with a typical stoichiometry of 3 Na(+) : 1 dicarboxylate. SLC13A2 is a 592-residue multi-pass membrane protein, with 13 predicted transmembrane regions and a molecular weight of ~64 kDa, located at the apical plasma membrane of renal and intestinal cells.

Other names

Na(+)/dicarboxylate cotransporter 1NaDC-1NADC1Renal sodium/dicarboxylate cotransporterSDCT1SLC13A2

Drugs or modulators targeting SLC13A2 would generally function by inhibiting or modulating sodium-dicarboxylate cotransport, which could increase urinary citrate excretion, thereby reducing kidney stone formation (hypothetical, based on known biochemical functions)