Solute carrier family 15 member 3 (SLC15A3)

Solute carrier family 15 member 3 is an intracellular membrane-bound transporter that utilizes proton-coupling to translocate small peptides, free histidine, and microbial-derived peptidoglycans from the lumen of endolysosomal compartments to the cytosol[1][2][7]. By facilitating the import of bacterial peptidoglycans (e.g., muramyl dipeptide), it enables detection and activation of toll-like receptors and NOD-like receptors, making it a key component in innate immune signaling[1][2][7]. Its dysfunction or modulation has repercussions in immunity-related diseases, including experimental models of pulmonary fibrosis and human genetic syndromes such as Hypotrichosis 4[1][4][6]. There is current structural and molecular interest due to its substrate recognition functions and immunological relevance[2].

Other names

SLC15A3Peptide/histidine transporter 3PHT3Solute carrier family 15 member 3 protein

Modulation of peptide and histidine transport, affecting immune response signaling and pathogen recognition[2][7]