Solute carrier family 16 member 14 (SLC16A14)

Solute carrier family 16 member 14 (SLC16A14), also known as monocarboxylate transporter 14 (MCT14), is an orphan member of the large SLC16 transporter family that typically includes monocarboxylate transporters responsible for the transmembrane movement of substrates such as lactate, pyruvate, ketone bodies, and certain amino acids[2][4][3]. MCT14 has a unique expression pattern, with high mRNA levels in kidney and detectable expression in brain, testis, uterus, and liver. In the kidney, it localizes to the luminal membrane of the thick ascending limb of the loop of Henle and is highly responsive to dietary phosphate levels[2][4]. MCT14 is phylogenetically closest to the aromatic amino acid and thyroid hormone transporters MCT8 (SLC16A2) and MCT10 (SLC16A10), but its endogenous substrate remains unidentified—it does not appear to mediate classical monocarboxylates or thyroid hormones, and evidence for amino acid transport is currently inconclusive[2][4]. The specific physiological function, substrates, and clinical relevance of SLC16A14 remain unclear, though it is presumed to have a role in neuronal amino acid transport, renal nutrient sensing, or related biochemical processes[2][4].

Other names

Monocarboxylate transporter 14MCT14FLJ30794monocarboxylic acid transporter 14solute carrier family 16 (monocarboxylic acid transporters), member 14

Not established; substrate and drug interactions undetermined due to orphan transporter status