Solute carrier family 17 member 1 (SLC17A1)

Solute carrier family 17 member 1 (SLC17A1), also known as Sodium-dependent phosphate transport protein 1 (NPT1), is a membrane-bound protein primarily expressed in the apical membrane of renal proximal tubule cells and hepatocytes (UniProt Q14916). It functions as a voltage-driven organic anion exporter, playing a pivotal role in the renal secretion of urate, as well as the transport of various organic anions such as p-aminohippuric acid and certain drugs (PubMed: 21712383). Although initially characterized as a sodium-dependent phosphate transporter, its most significant physiological role in humans is the maintenance of urate homeostasis. Genetic polymorphisms in the SLC17A1 gene, particularly the rs1165196 (I269T) variant, are strongly associated with serum urate levels and the risk of developing gout, with gain-of-function mutations providing a protective effect against hyperuricemia (PubMed: 25605635). While no drugs currently on the market specifically target SLC17A1 as their primary mechanism, several uricosuric agents like probenecid and benzbromarone, as well as other medications like losartan and aspirin, are known to interact with it (NIH: PMC8226817). This polyspecificity makes SLC17A1 a critical site for potential drug-drug interactions and a promising target for the development of novel urate-lowering therapies. Understanding its transport mechanism and genetic variability is essential for optimizing the treatment of gout and managing renal drug clearance (NIH: PMC4412016).

Other names

NPT1NPT-1Sodium-dependent phosphate transport protein 1Sodium/phosphate cotransporter 1hNPT1

Inhibition of urate efflux and substrate competition