Solute carrier family 2, facilitated glucose transporter member 14 (SLC2A14)

Solute carrier family 2, facilitated glucose transporter member 14 (SLC2A14), also known as GLUT14, is a transmembrane protein belonging to the GLUT family of hexose transporters. It is highly homologous to GLUT3, sharing approximately 95% sequence identity, and is primarily expressed in the testes, suggesting a specialized role in providing energy for spermatogenesis and sperm motility [UniProt, PubMed: 22134353]. Beyond its physiological role in the male reproductive system, SLC2A14 has been identified as a potential oncogene or biomarker in various malignancies, including colorectal and gastric cancers, where its upregulation supports the increased glycolytic demands of tumor cells [PubMed: 30034153]. While it represents a potential therapeutic target for metabolic reprogramming in cancer, no specific small-molecule inhibitors are currently in clinical use [NCBI]. Research into SLC2A14 is ongoing to determine its precise substrate specificity and its viability as a druggable target without compromising reproductive health [PubMed: 28651534].

Other names

GLUT14Glucose transporter member 14SLC2A14

Facilitated diffusion of glucose across the plasma membrane down its concentration gradient.