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Solute carrier family 2 facilitated glucose transporter member 1 (GLUT-1)
- Target
- GLUT-1
- Molecular classification
- SLC (solute carrier) transporter
01
Overview
GLUT1 is a facilitative uniporter responsible for the energy-independent transport of glucose across cell membranes. It is highly expressed in erythrocytes and endothelial cells lining capillaries at the blood-brain barrier, ensuring adequate glucose supply. Mutations or dysfunctions in SLC2A1/GLUT1 can cause GLUT1 Deficiency Syndrome and other neurological disorders. SLC2A1/GLUT1 overexpression supports increased glycolysis in many cancers, representing an important target for cancer research/drug development.
- Other names
- SLC2A1GLUTGTRGlucose Transporter Protein Type IDYT17DYT18DYT9GTR_HUMANErythrocyte/brain glucose transporterHepG2 glucose transporterGTG1Solute carrier family 2 member 1
02
Mechanism of action
Passive facilitated diffusion—glucose moves down its concentration gradient without ATP consumption. The transporter alternates between outward-open and inward-open conformations allowing substrate binding/release on either side of the membrane depending on relative concentrations.
03
Biological functions
Facilitative glucose transportBasal glucose uptakeGlucose transport across the blood-brain barrierDehydroascorbic acid (oxidized vitamin C) transport/recycling
04
Disease associations
GLUT1 Deficiency SyndromeIdiopathic generalized epilepsy type 12Dystonia type 9Stomatin-deficient cryohydrocytosisCancer
05
Safety considerations
Overexpression supports increased glycolysis ("Warburg effect") seen in many cancers—promoting tumor growth/metastasis through enhanced glycometabolism. Thus, it represents an important target for cancer research/drug development.
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