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Solute Carrier Family 2 Member 1 (GLUT1)
- Target
- GLUT1
- Molecular classification
- SLC Transporter, Transporter, Facilitative Glucose Transporter
01
Overview
GLUT1, encoded by the SLC2A1 gene, is a facilitative glucose transporter protein crucial for transporting glucose across cell membranes. It is essential for tissues with high energy demands, particularly the brain and erythrocytes. GLUT1 mediates glucose uptake in a concentration-dependent manner and is implicated in various diseases, including GLUT1 deficiency syndrome, epilepsy, and cancer. Its role in cancer metabolism makes it a target for therapeutic intervention.
- Other names
- GLUTGLUTBGTR1_HUMANDYT17DYT18DYT9Erythrocyte/brain glucose transporter
02
Mechanism of action
Facilitates passive diffusion of glucose down its concentration gradient.
03
Biological functions
Glucose transportFacilitated diffusionVitamin C recyclingEnergy metabolism
04
Disease associations
GLUT1 Deficiency SyndromeEpilepsyDystoniaCancerStomatin-deficient cryohydrocytosisMetabolic disorders
05
Safety considerations
Altered cellular metabolism due to disruptionPotential for drug resistance in cancer
06
Biomarkers
GLUT1 expression levels in tumorsCerebrospinal fluid glucose levels in GLUT1 deficiencyErythrocyte GLUT1 levels
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