Solute carrier family 2 member 14 (SLC2A14)

Solute carrier family 2 member 14 (SLC2A14, also known as GLUT14) is an integral membrane protein that mediates facilitated diffusion of glucose and other hexoses like fructose and dehydroascorbate across the plasma membrane. It is a member of the GLUT family of glucose transporters and is highly conserved. Although it shares functional similarity with other glucose transporters (notably SLC2A3/GLUT3), its expression exhibits tissue specificity and its biological and pathological functions are still being elucidated. Diseases associated with SLC2A14 mutations include arterial tortuosity syndrome and neuronal ceroid lipofuscinosis. No drugs are currently reported to act as direct and selective modulators of SLC2A14 in clinical use

Other names

SLC2A14GLUT14SLC2A3P3Glucose transporter type 14Solute carrier family 2 (facilitated glucose transporter), member 14GLUT-14

Modulation or inhibition of glucose and hexose transport across cell membranes; mechanisms for drugs would involve blocking or altering transporter activity