Solute carrier family 20 member 1 (SLC20A1) (SLC20A1)

Solute carrier family 20 member 1 (SLC20A1), also known as Glvr-1 or PiT-1, is a sodium-dependent inorganic phosphate transporter that plays a critical role in maintaining cellular phosphate homeostasis [1, 6]. It was originally identified as the cellular receptor for the gibbon ape leukemia virus (GALV) and feline leukemia virus subgroup B (FeLV-B) [1, 3]. Beyond its role in viral entry, SLC20A1 is essential for various physiological processes, including bone mineralization and cell proliferation, and its knockout is embryonic lethal in mice [7, 40]. In disease contexts, overexpression of SLC20A1 is associated with vascular calcification and is a poor prognostic marker in several cancers, including breast and prostate cancer, where it promotes aggressive tumor growth and resistance to therapy [24, 43]. While no drugs are currently approved specifically to target SLC20A1, it is an active area of research for therapeutic intervention in calcification disorders and oncology, with experimental inhibitors like EOS789 showing promise in preclinical studies [40].

Other names

Glvr-1GLVR1PiT-1PIT1Gibbon ape leukemia virus receptor 1Sodium-dependent phosphate transporter 1Phosphate transporter 1

Inhibition of sodium-dependent phosphate transport