Solute carrier family 22 member 10 pseudogene (SLC22A10P)

In humans, solute carrier family 22 member 10 pseudogene (SLC22A10P, ENSG00000256181) is a unitary pseudogene within the SLC22 organic ion transporter family. Unlike functional members of the SLC22 family, human SLC22A10P is inactivated due to a fixed missense mutation (Pro220), which disrupts its protein coding potential and prevents plasma membrane localization and transport activity. While orthologs in great apes and other primates function as steroid glucuronide transporters (notably for estradiol-17β-glucuronide), the human version does not produce a functional transporter, meaning it lacks canonical biological function and clinical relevance. Its evolutionary inactivation may have contributed to changes in steroid metabolism unique to humans, but it is not currently relevant for therapeutic targeting, drug development, or biomarker use[1][2]. If structured data extraction is required for bioinformatics or target annotation, this entry should be handled as a non-functional pseudogene and excluded from lists of valid therapeutic targets.

Other names

SLC22A10PSLC22A10 pseudogeneOrganic anion transporter pseudogene 10OAT5 pseudogene