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Target intelligence / Profile preview
Solute Carrier Family 22 Member 11 (OAT4)
- Target
- OAT4
- Molecular classification
- Solute Carrier Family, Transporter
01
Overview
Solute carrier family 22 member 11 (SLC22A11) encodes the organic anion transporter 4 (OAT4). OAT4 is a sodium-independent antiporter that mediates the transport of various organic anions, including conjugated steroids, prostaglandins, and uric acid. It is expressed primarily in the kidney and placenta, playing a role in renal excretion and fetal protection.
- Other names
- hOAT4SLC22A11
02
Biological functions
Transmembrane transportOrganic anion transportProstaglandin transportUrate transport
03
Disease associations
NephrolithiasisHyperuricemia
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