Target intelligence / Profile preview

Solute Carrier Family 22 Member 12 (URAT1)

Target: URAT1
Molecular classification: Organic anion transporter (OAT) family, Solute carrier family 22, Transporter

Overview

URAT1 (Solute Carrier Family 22 Member 12) is a urate-anion exchanger predominantly expressed in the apical membrane of proximal tubule cells in the kidney. It plays a critical role in regulating blood uric acid levels by mediating the reabsorption of urate from urine back into the bloodstream in exchange for other organic anions. URAT1 is a therapeutic target for hyperuricemia and gout, with several drugs inhibiting its activity to promote renal excretion of uric acid.

Other names: OATL4RSTOAT4LRenal-specific transporterUrate anion exchanger 1

Mechanism of action

Inhibition of urate reabsorption in the kidney, promoting uric acid excretion.

Biological functions

Urate transportAnion exchangeRegulation of blood uric acid levelsMaintenance of serum uric acid homeostasisAntioxidant defense

Disease associations

Renal hypouricemiaHyperuricemiaGout

Safety considerations

Potential drug interactions with other organic anion substratesRisk of adverse effects associated with altered uric acid levels (e.g., nephrolithiasis)Exercise induced acute kidney injury in Renal hypouricemia

Interacting drugs

Lesinurad

6 more in the full profile.

Biomarkers

Serum uric acid levelsGenetic variants of SLC22A12 (e.g., Trp258Ter/W258X)

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