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Solute Carrier Family 22 Member 13 (OAT10)
- Target
- OAT10
- Molecular classification
- Transporter, Solute Carrier, Anion Exchanger
01
Overview
Solute carrier family 22 member 13 (SLC22A13), also known as OAT10, is an anion antiporter primarily expressed in the kidneys and intestines. It mediates the transport of urate, orotate, and nicotinate in exchange for other anions, playing a crucial role in renal uric acid reabsorption and potentially affecting vitamin metabolism. Its involvement in uric acid transport makes it relevant to hyperuricemia and kidney stone formation.
- Other names
- OCTL1OCTL3ORCTL-3ORCTL3
02
Mechanism of action
Modulation of anion exchange and urate/orotate/nicotinate transport.
03
Biological functions
Urate transportOrotate transportNicotinate transportAnion exchange
04
Disease associations
HyperuricemiaUric Acid NephrolithiasisKidney Disease
05
Safety considerations
Potential for drug-drug interactions due to involvement in drug transport.Altered expression may impact uric acid levels.
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