Solute carrier family 22 member 17 (SLC22A17)

Solute carrier family 22 member 17 (SLC22A17), also known as 24p3 receptor, Lipocalin-2 receptor, and several other aliases, is a multi-pass membrane protein classified as both a transporter and a receptor. It binds to the iron-carrying protein lipocalin-2 (LCN2/NGAL), mediating iron uptake or efflux depending on LCN2's iron status. SLC22A17 plays essential roles in iron homeostasis, cell differentiation, apoptosis regulation, and the modulation of inflammatory processes. It is expressed in various tissues and has been implicated in cancers (notably as a biomarker in lung cancer), as well as inflammatory conditions. Currently, there are no approved drugs that specifically target SLC22A17, but its role in disease and physiologic regulation makes it a potential therapeutic target[1][2][9].

Other names

24p3 receptor24p3RBrain-type organic cation transporterLipocalin-2 receptorNeutrophil gelatinase-associated lipocalin receptorNgalRBOCTBOIT

Regulates iron import/export via binding to the iron-carrying protein lipocalin-2 (LCN2/NGAL), inducing downstream effects on apoptosis and inflammation (potential mechanism for drug action if targeted)[1][2].