Solute carrier family 22 member 20 (Oat6) (Oat6)

Solute carrier family 22 member 20, commonly known as Organic anion transporter 6 (Oat6), is a transmembrane protein primarily expressed in the olfactory epithelium and the kidney of mice (UniProt Q8R4X4). As a member of the SLC22 family, it functions as a polyspecific transporter that facilitates the movement of various endogenous and exogenous organic anions across cell membranes (PMID: 15145987). In mice, Oat6 is notably involved in the transport of odorants and pheromones, suggesting a specialized role in olfactory signaling and chemical communication (PMID: 16303770). Pharmacologically, Oat6 is inhibited by drugs such as probenecid and interacts with various organic acids, including certain antibiotics like Penicillin G and steroids like estrone sulfate (PMID: 15145987, PMID: 23023032). Understanding Oat6 is crucial for predicting drug-drug interactions and the systemic clearance of organic anions, particularly in the context of nasal drug delivery and olfactory physiology. While its human ortholog is less characterized, Oat6 remains a subject of interest for understanding the physiological handling of organic anions and the development of targeted delivery systems.

Other names

Organic anion transporter 6Slc22a20mOat6Ust4Urate transporter 4

Competitive inhibition of organic anion transport (PMID: 15145987)