Solute carrier family 22 member 25 (SLC22A25)

Solute carrier family 22 member 25 (SLC22A25) is a membrane-bound organic anion transporter belonging to the SLC22 family, expressed primarily in epithelial barriers such as the kidney, liver, and intestines. It is predicted to mediate the uptake and excretion of organic anions and cations, playing a critical role in drug pharmacokinetics and endogenous metabolite regulation. Genetic variation in SLC22A25 can impact its expression and function, influencing disease susceptibility (notably atrial fibrillation) as well as drug toxicity and efficacy. Its precise substrate profile is still being researched, but SLC22A25 is a member of a transporter family that governs the body's handling of a wide variety of drugs, toxins, and physiological metabolites. Key facts: - SLC22A25 is widely considered a bona fide drug transporter in the organic anion transporter (OAT) subclass, though its endogenous and drug substrates are incompletely characterized as of 2025. - Biological and clinical interest centers around its role in pharmacokinetics and possible disease susceptibility, especially for cardiac arrhythmias. - There are no major reports of misspelling or target confusion associated with "SLC22A25" as of current knowledge.

Other names

UST6HIMTPMGC120420Organic anion transporter UST6putative UST1-like organic anion transporterMGI:2442751MGI:2385316MGI:3042283MGI:3645714MGI:3605624MGI:2442750

Transmembrane transport (carrier-mediated uptake and excretion of organic anions/cations; involved in drug absorption and elimination)