Solute carrier family 22 member 7 (SLC22A7)

Solute carrier family 22 member 7 (SLC22A7), commonly called organic anion transporter 2 (OAT2), is a sodium-independent transmembrane transporter protein highly expressed in the liver and kidney, and to a lesser extent in lung and other tissues[2][3][4][8]. It mediates the bidirectional transport of a wide variety of organic anions and cations, including endogenous substances (e.g., urate, glutamate, creatinine, nucleotides, prostaglandins) and many drugs (e.g., methotrexate, antibiotics, antivirals)[2][3][8]. SLC22A7 is an integral membrane protein, localized to the basolateral membrane of hepatocytes and renal proximal tubule cells, where it plays a key role in drug disposition, elimination of toxins, and regulation of cGMP signaling[1][3][6][7]. SLC22A7 is associated with genetic disorders of metabolism (gout, bilirubin metabolic disorders) and is increasingly recognized for its importance in clinical pharmacology, serving as a biomarker for drug response and a potential target for modulating chemotherapy efficacy and safety[8].

Other names

Organic anion transporter 2OAT2hOAT2Novel liver transporterNLTOrganic anion transporter 11hOAT11Liver-specific transporter

Inhibition or modulation of organic anion exchange activity; Alteration of renal or hepatic excretion of drugs and metabolites; Regulation of intracellular and extracellular cGMP levels (which may impact cGMP-dependent signaling)[6][7]