Solute carrier family 25 member 25 (SLC25A25)

Solute carrier family 25 member 25 (SLC25A25) is a mitochondrial transporter protein localized to the inner mitochondrial membrane. It functions predominantly as an antiporter for adenyl nucleotides, mediating the exchange of ATP-Mg and inorganic phosphate (Pi) and thereby regulating the mitochondrial pool of adenine nucleotides according to cellular energetic demands. SLC25A25 is a member of the mitochondrial carrier family (SLC25), which is the largest solute transporter family in humans. It plays a critical role in cellular energy homeostasis, with activity modulated by calcium binding. Dysfunction or mutation in SLC25A25 is associated with human diseases such as nephrolithiasis and combined oxidative phosphorylation deficiency, highlighting its importance in mitochondrial physiology and pathology[1][2][3][5][6].

Other names

Mitochondrial adenyl nucleotide antiporter SLC25A25APC3KIAA1896MCSC3SCAMC2UNQ549/PRO1106SCaMC-2PCSCLMCSCMitochondrial ATP-Mg/Pi carrier protein 3Mitochondrial Ca(2+)-dependent solute carrier protein 3Short calcium-binding mitochondrial carrier protein 2Small calcium-binding mitochondrial carrier 2Solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25

Not applicable/unknown for drugs due to the absence of directly targeting compounds; mechanistically, SLC25A25 operates as an ATP-Mg/Pi antiporter in mitochondria, supporting nucleotide exchange essential for cellular energy management[1][2][3][5].