Solute carrier family 25 member 43 (SLC25A43)

Solute carrier family 25 member 43 (SLC25A43) is an inner mitochondrial membrane transporter in the SLC25 gene family, which comprises proteins responsible for translocating a variety of metabolites, nucleotides, and cofactors across the mitochondrial inner membrane. The specific substrate transported by SLC25A43 remains unidentified, but it likely influences mitochondrial function, redox status, and cell cycle progression. SLC25A43 functions as a regulator of cell proliferation and is implicated as a tumor suppressor in HER2-positive breast cancer, where it is frequently deleted or epigenetically silenced. Its loss can alter the cell cycle, enhance resistance to oxidative stress, and modulate the efficacy of chemotherapeutic agents such as paclitaxel and trastuzumab. Reduced SLC25A43 expression can enhance antioxidant capacity and promote cancer cell survival under stress conditions, suggesting important roles in both metabolism and cancer biology[2][3][4][5].

Other names

SLC25A43Solute carrier family 25 member 43mitochondrial carrier family member 43

Modulation of cell susceptibility to cytotoxicity and cell cycle arrest by influencing drug responses (for paclitaxel and trastuzumab)[3]