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Target intelligence / Profile preview
Solute carrier family 25 member 44 (SLC25A44)
- Target
- SLC25A44
- Molecular classification
- Transporter, Mitochondrial carrier protein
01
Overview
Solute carrier family 25 member 44 (SLC25A44) is a mitochondrial transporter protein that belongs to the SLC25 family of mitochondrial carrier proteins. It facilitates the import of branched-chain amino acids (valine, leucine, isoleucine) into mitochondria, particularly in brown adipose tissue, where these amino acids are catabolized for thermogenesis[4]. SLC25A44 has also been identified as a transporter of ubiquinone precursors (such as hydroxybenzoic acid and aminobenzoic acid), linking primary metabolism of energy to secondary metabolites and playing a role in mitochondrial electron transport chain function[3]. The gene is highly conserved, essential for ubiquinone biosynthesis, and ubiquitously expressed in higher eukaryotes. Genetic variants have been associated with some forms of cerebral and vascular disorders[4].
- Other names
- KIAA0446FLJ90431S2544SLC25A44
02
Biological functions
Mitochondrial transport of branched-chain amino acids (BCAA)Regulation of energy metabolism in brown adipose tissueTransport of ubiquinone precursors(Potential role) Electron transport chain function
03
Disease associations
Metabolic disorders (via BCAA metabolism)Brain small vessel diseaseCerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1
04
Safety considerations
Deficiency may disrupt BCAA metabolism and thermogenesisDefects in ubiquinone precursor transport could impair mitochondrial respiration
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