Solute carrier family 25 member 45 (SLC25A45)

Solute carrier family 25 member 45 (SLC25A45) is a predicted mitochondrial inner membrane transporter and a member of the SLC25 (mitochondrial carrier) family, which is responsible for the import and export of metabolites in the mitochondria[1][2][4][6][7]. Although the precise endogenous substrate of SLC25A45 remains unidentified, phylogenetic analysis places it within a clade of amino acid transporters, suggesting a potential role in transporting amino acids or related molecules across the mitochondrial inner membrane[2]. Expression studies indicate SLC25A45 is widely but modestly expressed in human tissues, with higher levels in testis, liver, and kidney, and lower expression in brain regions[6]. Functional studies in closely related family members point to a significant role for SLC25 carriers in mitochondrial metabolism, bioenergetics, and overall cellular metabolic regulation[2][4]. SLC25A45 itself remains poorly characterized, with no established pharmacological modulators, disease associations, or clinical interventions directly targeting it[2][7].

Other names

SLC25A45Solute carrier family 25 member 45