Solute carrier family 25 member 48 (SLC25A48)

SLC25A48 (Solute carrier family 25 member 48) is a **mitochondrial inner membrane transporter** that mediates the import of choline into mitochondria, where it facilitates the catabolism of choline to betaine—a critical metabolite for one-carbon metabolism, mitochondrial function, and cell survival[1][2]. This transporter is **required for normal mitochondrial respiration, maintenance of mitochondrial membrane integrity, and efficient thermogenesis in brown adipose tissue**[1][2]. Loss of SLC25A48 impairs choline import into the mitochondrial matrix, reduces betaine production, causes mitochondrial lipid imbalance, increases reactive oxygen species (ROS), and leads to defective cell proliferation and survival, making it relevant for both metabolic diseases and cancer biology[1][2]. Genome-wide studies have linked SLC25A48 polymorphisms to changes in circulating choline levels and disease risk[1][2]. No drugs directly target SLC25A48 to date, and there are no established therapeutic uses or mechanisms of inhibition known.

Other names

SLC25A48FLJ44862CTC-321K16.1