Solute carrier family 25 member 53 (SLC25A53)

Solute carrier family 25 member 53 (SLC25A53) is a mitochondrial inner membrane transporter that belongs to the SLC25 family of mitochondrial carrier proteins, which are responsible for transporting a variety of metabolites, nucleotides, and cofactors between the cytosol and the mitochondrial matrix[1][2][4][6][8]. SLC25A53 is classified as an orphan transporter, meaning its precise physiological substrates are not definitively identified, although it is predicted to participate in NAD transmembrane transport[5]. It is expressed in mitochondria as a multi-pass membrane protein[1]. Genetic associations suggest possible links to progressive external ophthalmoplegia and spastic paraplegia[5]. No direct drug interactors or validated roles as a drug target have been described in the current literature and drug databases[5][7]. As a member of the mitochondrial carrier family, SLC25A53 may play roles in energy metabolism and mitochondrial maintenance, but most of its biological and clinical roles remain to be clarified[1][2][5].

Other names

MCART6Mitochondrial carrier triple repeat protein 6S2553_HUMANsolute carrier family 25, member 53