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Target intelligence / Profile preview
Solute carrier family 25 member 6 (SLC25A6)
- Target
- SLC25A6
- Molecular classification
- Transporter, Mitochondrial carrier protein, Solute carrier (SLC) family
01
Overview
Solute carrier family 25 member 6 is a mitochondrial inner membrane protein responsible for the bidirectional exchange of ADP and ATP between the cytoplasm and the mitochondrial matrix, facilitating ATP synthesis and cellular energy provision. It also plays a key role in mitochondrial permeability transition pore complexes (PTPC), regulating apoptosis through pore opening, and can participate in mitochondrial uncoupling and thermogenesis. SLC25A6 is widely expressed and highly conserved; disruptions in its function may contribute to disease states such as cancer, neurodegeneration, and mitochondrial disorders.
- Other names
- Adenine nucleotide translocase 3 (ANT3)Adenine nucleotide translocator 3ADP/ATP translocase 3AAC3ANT 2ANT 3ANT3Y
02
Mechanism of action
Inhibition or modulation of ADP/ATP exchange affects cell energy status; Modulation of mPTP opening controls apoptosis induction.
03
Biological functions
ADP/ATP translocation (antiporter activity)Regulation of mitochondrial permeability transition pore (mPTP)Apoptosis (induces cell death through mitochondrial product release—PTPC)Cellular energy metabolismMitochondrial uncoupling/thermogenesis
04
Disease associations
Cancer (through apoptosis regulation)Neurodegenerative disease (Alzheimer's disease pathway involvement)Infection (reported association with plague)Other (cell death, mitochondrial dysfunction)
05
Safety considerations
Potential for excessive apoptosis/cell death if over-inhibited (relevant in tissue injury or degenerative disease)Risk of mitochondrial toxicity due to disruption of ATP supply
06
Interacting drugs
atractyloside
1 more in the full profile.
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