Solute carrier family 26 member 11 (SLC26A11)

Solute carrier family 26 member 11 (SLC26A11) is a sodium-independent, DIDS-sensitive anion transporter, primarily mediating the movement of sulfate, bicarbonate, chloride, and oxalate ions across cellular membranes. It is a member of the SLC26 family of anion exchangers that play essential roles in maintaining intracellular electrolyte balance and homeostasis. SLC26A11 is highly expressed in placenta, kidney, and brain, and is thought to facilitate specialized sulfate transport into high endothelial venule endothelial cells, potentially cooperating with SLC26A2. Beyond surface ion exchange, SLC26A11 has emerging importance in lysosomal function and regulation of degradative pathways, suggesting roles in autophagy and cellular clearance as part of the CLEAR network regulated by TFEB. Diseases associated with dysfunction of SLC26A11 include mucopolysaccharidosis IIIA and possibly other lysosomal storage diseases.

Other names

Sodium-independent sulfate anion transporterSolute carrier family 26 (anion exchanger) member 11SLC26A11S2611_HUMAN

Inhibition of sulfate transport by anion exchanger inhibitors (e.g., DIDS); transport of sulfate, chloride, bicarbonate, oxalate across the membrane