Target intelligence / Profile preview

Solute carrier family 26 member 4 (SLC26A4)

Target: SLC26A4
Molecular classification: Transporter, Anion Exchanger

Overview

The SLC26A4 gene encodes pendrin, a membrane protein that functions as an anion exchanger. It mediates the electroneutral exchange of chloride (Cl⁻), iodide (I⁻), bicarbonate (HCO₃⁻), hydroxide (OH⁻), and formate across cell membranes. Pendrin is primarily expressed in the inner ear, thyroid gland, kidney, and also found in the liver and airway epithelium. Mutations in SLC26A4 are associated with Pendred Syndrome, DFNB4 nonsyndromic hearing loss and congenital hypothyroidism.

Other names: Pendrin

Biological functions

Anion exchange (Cl⁻/I⁻/HCO₃⁻)Maintenance of ionic composition

Disease associations

Pendred SyndromeDFNB4 Nonsyndromic Hearing LossCongenital Hypothyroidism

Safety considerations

Hearing lossThyroid dysfunctionAirway hyperreactivity

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