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Solute carrier family 26 member 4 antisense RNA 1 (SLC26A4-AS1)
- Target
- SLC26A4-AS1
- Molecular classification
- Other (Long non-coding RNA, lncRNA)
01
Overview
Solute carrier family 26 member 4 antisense RNA 1 (SLC26A4-AS1) is a long non-coding RNA (lncRNA) located on the antisense strand of the SLC26A4 gene. It does not encode a protein, but instead regulates the expression of the SLC26A4 gene, which encodes pendrin—a transporter involved in the movement of chloride and bicarbonate ions. Dysregulation of SLC26A4-AS1 has been associated with cancer, especially rectal cancer, where decreased expression acts as a negative regulator of tumor cell proliferation, migration, and invasion via sponging microRNA-3174 (miR-3174)[2]. It has also been linked to Pendred syndrome, congenital hypothyroidism, and kidney stones through its regulatory effects on SLC26A4 gene expression[1]. SLC26A4-AS1 is under investigation as a potential plasma biomarker for the diagnosis and prognosis of rectal cancer, but it is not currently considered a direct therapeutic target or receptor[2][1].
- Other names
- SLC26A4-AS1solute carrier family 26 member 4 antisense RNA 1lncRNA SLC26A4-AS1
02
Biological functions
Regulation of gene expression (specifically SLC26A4 mRNA expression)Modulation of cell proliferation and apoptosisRegulation of cancer cell migration and invasion
03
Disease associations
Cancer (notably rectal cancer, based on biomarker studies)Pendred syndrome (indirectly, through SLC26A4 gene dysregulation)Congenital hypothyroidism (indirectly, through SLC26A4 gene dysregulation)Kidney stone formation (indirectly, through SLC26A4 gene dysregulation)
04
Biomarkers
Plasma levels of SLC26A4-AS1 as a diagnostic biomarker for rectal cancer
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