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Solute carrier family 26 member 7 (SLC26A7)
- Target
- SLC26A7
- Molecular classification
- Transporter, Anion channel
01
Overview
Solute carrier family 26 member 7 (SLC26A7) is an anion channel/transporter highly expressed in the kidney and thyroid, where it mediates the sodium-independent, transmembrane exchange and transport of multiple anions including chloride, sulfate, oxalate, bicarbonate, and others[1][2][5]. It plays an essential role in maintaining pH and ion homeostasis, with particular importance in renal acid-base regulation and thyroid hormone biosynthesis[1]. Dysfunction or mutation of SLC26A7 is linked to disorders such as congenital hypothyroidism and may impact general electrolyte or acid-base balance[1]. SLC26A7 is a member of the broader solute carrier family 26, a family of multifunctional anion exchangers[4]. No established interacting drugs or biomarker indications are currently noted.
- Other names
- SUT2Anion exchange transporterSolute carrier family 26 (anion exchanger), member 7Sulfate anion transporter 2Solute carrier family 26, member 7Sulfate anion transporter
02
Mechanism of action
Modulation of anion exchange for chloride, sulfate, bicarbonate, and other ions Mediates electrogenic and electroneutral transport depending on ion context
03
Biological functions
Chloride channel activitySulfate transmembrane transporter activityTransport of bromide, iodide, nitrate, gluconate, thiocyanate, bicarbonate, oxalateMaintains ion and pH homeostasisInvolved in thyroid hormone synthesis
04
Disease associations
Congenital hypothyroidismAssociated with thyroid dysfunctionPossible roles in metabolic acidosis and fluid/electrolyte imbalance
05
Safety considerations
Potential risk of disrupting electrolyte or acid-base balance if inhibited or dysfunctionalMutations can cause thyroid and kidney dysfunction
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