Solute carrier family 27 member 1 (SLC27A1) (SLC27A1)

Solute carrier family 27 member 1 (SLC27A1), also known as Fatty acid transport protein 1 (FATP1), is an integral membrane protein that facilitates the cellular uptake of long-chain fatty acids (LCFAs) and exhibits very long-chain acyl-CoA synthetase activity (UniProt, P48410). It is highly expressed in insulin-sensitive tissues such as adipose tissue and skeletal muscle, where it plays a pivotal role in lipid metabolism by coupling fatty acid transport with esterification to prevent efflux (PubMed, 10430899). In the context of disease, FATP1 is a significant factor in the development of insulin resistance and obesity, as its activity influences the partitioning of lipids between storage and oxidation (PubMed, 15637156). Targeting FATP1 mRNA or the protein itself is a proposed therapeutic strategy for metabolic syndrome; for instance, antisense oligonucleotides (ASOs) targeting SLC27A1 mRNA can reduce fatty acid uptake and improve glucose tolerance in animal models (PubMed, 16459284). Small molecule inhibitors like Lipofermata have also demonstrated the ability to block FATP1-mediated lipid transport, highlighting its potential as a druggable target for treating nonalcoholic fatty liver disease and type 2 diabetes (PubMed, 22134911).

Other names

Fatty acid transport protein 1FATP1ACSVL5Very long-chain acyl-CoA synthetase 5Fatty acid transport protein 1 mRNA

Inhibition of long-chain fatty acid transport and very long-chain acyl-CoA synthetase activity to reduce intracellular lipid accumulation.