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Solute Carrier Family 3 Member 2 (SLC3A2)
- Target
- SLC3A2
- Molecular classification
- Transmembrane glycoprotein, Solute Carrier, Transporter, Amino Acid Transporter, Polyamine Transporter
01
Overview
SLC3A2 is a transmembrane glycoprotein that functions as the heavy subunit of heterodimeric amino acid and polyamine transporters. It is crucial for trafficking its partner light-chain transporters (SLC7 family) to the plasma membrane and enabling their function. Specifically, it forms complexes like LAT1/SLC7A5, responsible for transporting neutral branched-chain and aromatic amino acids. Under certain conditions, SLC3A2 can facilitate polyamine uptake, particularly putrescine, via an antiport mechanism. Its interaction with integrins also links it to cell growth and tumorigenesis, making it a potential therapeutic target in cancer and metabolic diseases.
- Other names
- 4F2 cell-surface antigen heavy chain4F2hcCD98CD98HCMDU1NACAE
02
Mechanism of action
Forms heterodimers with SLC7 family members to facilitate substrate transport across cell membranes; influences cell signaling pathways.
03
Biological functions
Amino acid transportPolyamine transportTrafficking of light-chain transportersIntegrin-mediated signalingCell growth regulation
04
Disease associations
CancerMetabolic disorders
05
Safety considerations
Upregulation in certain cancers may limit therapeutic window.Disrupting amino acid or polyamine homeostasis could have broad effects.
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