Solute carrier family 30 member 10 (SLC30A10)

Solute carrier family 30 member 10 (SLC30A10) is a transmembrane protein that belongs to the cation diffusion facilitator (CDF) superfamily of metal transporters[1][5]. Unlike most SLC30 family members, which typically transport zinc, SLC30A10 is specialized for exporting manganese and plays a critical role in manganese homeostasis. It is highly expressed in the liver, brain, small intestine, and testis, where it helps to excrete excess manganese into the bile and maintain safe intracellular concentrations[1][3]. Loss-of-function mutations in the SLC30A10 gene are the cause of inherited hypermanganesemia with dystonia, polycythemia, and cirrhosis—characterized by increased manganese in neurological and hepatic tissues, leading to movement disorders (dystonia, parkinsonism), liver disease, and hematological abnormalities[3][4][6]. SLC30A10 is essential for protecting cells, especially neurons and hepatocytes, from manganese toxicity, and is regulated by cellular manganese levels and potentially by hypoxia signaling pathways (HIF)[2]. There is active research into pharmacological modulation of SLC30A10 as a strategy for treating manganese toxicity[6].

Other names

Zinc transporter 10ZnT-10manganese transporter SLC30A10ZNT10ZNT8ZRC1DKFZp547M236zinc resistance conferring homolog (S. cerevisiae)HMNDYT1HMDPC

Drugs or interventions targeting SLC30A10 would primarily work by modulating manganese transport/efflux to reduce intracellular manganese and prevent toxicity[6][2].